Quantum pharmacogenomics applied to ageing
The general aim of project “QHealth: Quantum pharmacogenomics applied to ageing” is mainly human-oriented: the increase in longevity and quality of life of older adults. QHealth will address this issue conducting a research about the correlation among the genetic variables and other variables related to the health history of the patients. The study will include the adverse reactions to prescribing drugs in order to predict unwanted side effects of a specific one. This will be analyzed in function of the drugs consumption history of the patients, the reactions the older adult has experimented, and his/her physiological and genetic limitations.
In order to achieve this aim, QHealth will study and design scientific, methodological and technological models to establish the scientific and technical fundamentals of a classical/quantum hybrid system able to carry out optimizations and simulations whose realization in classical hardware is not possible in acceptable timescales. The hybrid system, in combination with classical health applications, will give its outputs to medical professionals involved in prescribing drugs to older adults. This will not only have a human impact it will also have a financial impact because it will optimize the investments that health systems make in financing drugs and address the adverse effects that drugs often generate in older people.
According to the general aim of the QHealth project described above, it has been selected the “Misión” of the “Misiones Ciencia e Innovación” call for innovation projects supported by Centre for the Development of Industrial Technology (CDTI). The focus of the research project is the following: “To address illness and necessities related to ageing”. The project includes a wide range and diversity of research tasks, as it is described in the report, in the 3 fields defined for this “Misión”.
In the scientific field, the most important aspects that allow QHealth project to reach the top world position of basic research in quantum pharmacogenomics and also validate the points to improve in the “Misión” selected, are the following:
- QHealth addresses the hypothesis about the existence of a correlation among physiological and genetic limitations, consumption of prescribing drugs history, and the active principles an older adult has been exposed to, including the reactions to these and the possible side effects of new drugs in near future. In the research project, will be carried out simulations that allow the prediction of those events by means of the implementation of quantum algorithms. The results will contribute to the increase in longevity and quality of life of older adults.
- QHealth focuses on the most relevant factors to avoid side effects and errors in drug prescription and medical treatments very frequent in the case of older adult, for example, when doctors prescribe a new drugs or introduce modification regarding to the drugs the patient has being taking. Quantum simulations allow to study these issues, something that it is impossible with classical computer simulations.
- QHealth studies the creation of a methodological and technological environment that, according to the results obtained, will allow the development of future health software solution which use quantum computing for the optimization of the prescribing drugs administration. Moreover, the methodological and technological environment will allow to map the evolution of the patient related with the prescribing drug consumption and its genetic and environmental limitations onto quantum simulations. This will, for the first time, allow doctors the possibility of using the results offered by quantum computing technology for carrying out proactive ageing treatments.
The QHealth project will make all of the above possible thanks to the excellent scientific and technological complementation of the multidisciplinary teams of researchers and technologists from the companies aQuantum, Gloin and Madrija and the collaboration of each of them with Knowledge Creation Centers the University Institute of Biosanitary Research of Extremadura (INUBE) in collaboration with the Pharmacogenetics and Personalized Medicine Unit, the University of Extremadura (UEx) and the University of Castilla La Mancha (UCLM).
Given the research characteristics of the QHealth project and the state of art described in the summary, we think it will be a strong positive impact in terms of new results and the corresponding intellectually property right. In the execution of QHealth project, it will be defined multiple scientific and technological models. In this way, the strategy will consist in convert into utility models and the corresponding patent applications those models accepted by intellectually right advisers.
The aim of the members of the Consortium is to exploit the results of the research of the QHealth project for the development of the artifacts required for a hybrid classical/quantum platform specialized in services to pharmacogenomics applied to ageing. The execution of those future developments will be carried out both individually and with the collaboration of aQuantum Partner Network, the collaboration network of aQuantum in which participate all the companies of the Consortium. This assures the continuity of the research up to the practical application of results.
Finally, we recognize the interest in the QHealth project shown by different national and international institutions.
On November 27, the Center for the Development of Industrial Technology (CDTI) of the Ministry of Science and Innovation of Spain, made public the list of the granted projects among those submitted to the call for the 2020 CDTI Missions Program, within the framework of the Spanish program of Business Leadership in R&D. The detailed list of the granted and rejected projects can be consulted on the CDTI’s Science and Innovation Missions page.
In this Misiones call, the project “QHealth: Quantum Pharmacogenomics applied to aging”, which has a total budget of € 5,160,477.00, has been approved. The approval of the project by the Misiones 2020 program means that the QHealth project will receive a 3,671,281.69 euro grant from the CDTI.